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This high-volatility slot game comes with a Pay Anywhere feature which rewards players with winnings when they land eight or more matching symbols anywhere on the reels. This game also features an Free Spins bonus with multipliers up to 500x the bet. A practical trial that employs various investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity is necessary for practical trials to be valid, and it also helps to reduce bias in the results. Too much heterogeneity, however could cause issues with the design of the trial. Pragmatic Play is one of the biggest players on the live casino market, provides an array of traditional table games like Blackjack and Roulette. The live studios of the company in Romania and Malta provide customers with an authentic gambling experience, and a wide range of virtual betting options. 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Legality Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. Its software is designed to work on mobile devices and is compatible with multiple languages. It has established itself as one of the top gaming platforms in the casino industry despite its relative youth. Wolves is one of the latest games which is a five-reel slot machine that has a high RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat. The aim of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. They are usually requested by practitioners and policymakers to help inform their decisions. They can also be used to determine the causality of an intervention and its results. However, they shouldn't be used to substitute for explanatory studies. The concept of pragmatism is controversial and there are concerns about whether pragmatic trials can replace explanatory tests or if they should serve as an alternative to them. Schwartz and Lellouch1 made the distinction between explanation studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic research study, including recruitment, design, delivery of the intervention and follow-up. There is a positive trend in the number of pragmatic trials that have been published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember, however, that the majority of these studies were conducted in primary care settings.